An OIC provider reviews study information with a participant

Clinical research · Orlando, Florida

Shaping the future of healthcare through life‑changing clinical trials.

For more than 25 years, Orlando Immunology Center has helped develop every antiretroviral used to treat HIV today — and contributed to the cure for Hepatitis C.

25+years of clinical research
85+completed trials
100+peer-reviewed publications
Phase I–IVtrial experience
OIC study team members in an exam room

Participation benefits

Being part of a study should never be a burden.

For eligible participants, clinical trial participation may include:

  • Study medications provided at no cost
  • Study-related labs provided at no cost
  • Study-related visits provided at no cost
  • Monitoring by study-related providers
  • Transportation assistance, when needed, through Lyft, Uber, or bus passes
  • Stipend provided at each study visit

Our legacy

A legacy of innovation that makes OIC a trusted leader in clinical research.

OIC investigators have participated in the development of every commercially available HIV antiretroviral, played an important role in the cure for Hepatitis C, and partnered with the NIH on COVID-19 vaccines and treatments. When you join a study at OIC, you become part of that history.

100%of approved HIV antiretrovirals — we participated in their development
673participants enrolled in a single COVID-19 vaccine trial
318participants in the landmark DISCOVER PrEP trial
Hep Ccontributors to the trials that led to a cure

Research conducted with

  • Gilead
  • Merck
  • ViiV · GSK
  • Janssen
  • AbbVie
  • NIH · NIAID
  • Roche
  • TaiMed
OIC Inspired

Looking for clinical care instead?

Orlando Immunology Center is dedicated exclusively to clinical research. For primary care, sexual health and HIV medicine, visit OIC Inspired — our allied clinic, an independent practice founded by the same physicians.

Visit OIC Inspired →

Research team

Investigators who wrote the literature

Dr. Edwin DeJesus

Edwin DeJesus, MD, FACP, FIDSA

Medical Director · Principal Investigator

Dr. Federico Hinestrosa

Federico Hinestrosa, MD, FACP

Associate Medical Director

Latest news

From the research desk

Orlando Immunology Center

New once-monthly PrEP study now enrolling

OIC begins enrollment for a Phase 3 trial of a monthly oral tablet for HIV prevention.

Dr. Charlotte Rolle

Drs. Rolle and Hinestrosa featured on Spectrum News 13

Our investigators discussed the future of long-acting HIV prevention in Central Florida.

OIC at CROI 2026

OIC presents at CROI 2026

New data from our once-weekly oral treatment studies presented at the year’s leading HIV conference.